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Celebrities will share their personal experiences with the disease and will help answer phone calls from donors, Ziskin said.
The hourlong show also will include a performance of "Just Stand Up," a charity song featuring Mariah Carey, Mary J. Blige, Beyonce, Rihanna, Fergie, Miley Cyrus, Underwood and others.
Couric and her fellow network news anchors, Charles Gibson and Brian Williams, are set to host the show.
WDKX Radio is the only radio station in Rochester that is playing the song "Just Stand Up", the song recorded by many of today's top recording artist's.
The aim of Stand Up to Cancer is to raise funds for "translational research," Ziskin said, which encourages scientists to collaborate rather than compete, translating basic science into applicable therapies for patients. She compared the approach to the Manhattan project.
"We took the best and brightest and locked them up in Los Alamos and said you can't leave until you split the atom and create, unfortunately, a bomb," Ziskin said. "This is no less a problem, with half a million Americans a year dying from this disease. If we take best and brightest, encourage them and reward them for working together, the answers will come much more quickly."
